Human Heterogeneous Nuclear Ribonucleoprotein L, HNRNPL

Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion.

Exhibits a binding preference for CA-rich elements (PubMed: 11809897, PubMed: 22570490, PubMed: 24164894, PubMed: 25623890, PubMed: 26051023).

Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed: 2687284).

Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed: 11809897).