Human High mobility group protein B3,HMGB3 ELI

Multifunctional protein with various roles in different cellular compartments.

May act in a redox sensitive manner.

Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA.

Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity).

Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity).

Negatively regulates B-cell and myeloid cell differentiation.

In hematopoietic stem cells may regulate the balance between self-renewal and differentiation.

Involved in negative regulation of canonical Wnt signaling (By similarity).

{ECO:0000250|UniProtKB:O54879, ECO:0000250|UniProtKB:P09429, ECO:0000250|UniProtKB:P40618}.