Human Histatin-3, HTN3 ELI

Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle).

In addition, histatins exhibit antibacterial and antifungal activities.

His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis.

In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.