Human Histone Deacetylase 11, HDAC11 ELI

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).

Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Histone deacetylases act via the formation of large multiprotein complexes.