Human HIV-1 TAT-Interactive Protein 2,HTATIP2;TIP30 ELI

Oxidoreductase required for tumor suppression.

NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors.

May act as a redox sensor linked to transcription through regulation of nuclear import.

Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties.

Isoform 2 has an antiapoptotic effect.

{ECO:0000269|PubMed:10611237, ECO:0000269|PubMed:11313954, ECO:0000269|PubMed:15282309, ECO:0000269|PubMed:9174052}.