Human Homeobox protein Nkx-3.1,NKX3-1 ELI

Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor.

Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate.

Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.

{ECO:0000269|PubMed:19462257}.