Human Hyaluronan Synthase 1, HAS1 ELI

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer.

Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation.

This is one of the isozymes catalyzing that reaction.

Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity).