Human Icos Ligand, ICOSLG Primacu™ ELI

Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2.

It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function.

The structural features of ICOSL are crucial for its costimulatory function.

The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2.

B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production.

The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses.

Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.

Cancer Immunotherapy Co-stimulatory Immune Checkpoint Targets Immune Checkpoint Immune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: FCM Antibodies Immune Checkpoint Detection: WB Antibodies Immune Checkpoint Targets Immunotherapy Targeted Therapy