Human Immediate Early Response Gene 5 Protein, IER5 ELI

Plays a role as a transcription factor (PubMed: 22132193, PubMed: 25355627).

Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner (PubMed: 25355627, PubMed: 25816751).

Mediates negative transcriptional regulation of CDC25B expression (PubMed: 22132193).

Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A (PubMed: 25816751, PubMed: 26496226).

Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed: 22132193, PubMed: 25355627, PubMed: 26496226).

Involved in the cell cycle checkpoint and survival in response to ionizing radiation (PubMed: 19238419, PubMed: 22132193).

Associates with chromatin to the CDC25B promoter (PubMed: 22132193).