Human Inositol 1,4, 5-Trisphosphate Receptor Type 1, ITPR1 ELI

Intracellular Channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed: 27108797).

Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity).

Plays a role in ER stress-induced apoptosis.

Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).