Human Insulin-Degrading Enzyme, IDE ELI

Plays a role in the cellular breakdown of insulin, APP Peptides, IAPP Peptides, natriuretic Peptides, glucagon, bradykinin, kallidin, and other Peptides, and thereby plays a role in intercellular Peptide signaling (PubMed: 2293021, PubMed: 10684867, PubMed: 26968463, PubMed: 17051221, PubMed: 17613531, PubMed: 18986166, PubMed: 19321446, PubMed: 23922390, PubMed: 24847884, PubMed: 26394692, PubMed: 29596046, PubMed: 21098034).

Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (PubMed: 23922390, PubMed: 26394692, PubMed: 29596046).

Contributes to the regulation of Peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP (By similarity).

Plays a role in the degradation and clearance of APP-derived amyloidogenic Peptides that are secreted by neurons and microglia (PubMed: 9830016, PubMed: 26394692) (Probable).

Degrades the natriuretic Peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP (PubMed: 21098034).

Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous patients (PubMed: 21098034).

Involved in antigen processing.

Produces both the N terminus and the C terminus of MAGEA3-derived antigenic Peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I.

(Microbial infection) The membrane-associated isoform acts as an entry receptor for varicella-zoster virus (VZV).