Human Integrin alpha 2b,ITGA2B;CD41 ELI

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin.

It recognizes the sequence R-G-D in a wide array of ligands.

It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain.

Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen.

This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.