Human Integrin Alpha 4,ITGa4 ELI

Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin.

They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin.

They are also receptors for VCAM1.

Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1.

Integrin alpha-4/beta-7 is also a receptor for MADCAM1.

It recognizes the sequence L-D-T in MADCAM1.

On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines.

It may also participate in cytolytic T-cell interactions with target cells.

ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415).

ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).

{ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877}.