Human Integrin Alpha-5, ITGA5 ELI

Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen.

It recognizes the sequence R-G-D in its ligands.

ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed: 18635536, PubMed: 25398877).

ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed: 12807887, PubMed: 17158881).

ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed: 29030430).

ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed: 31331973).

(Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus.

(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19.

(Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.