Human Integrin beta-2,ITGB2 ELI

Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4.

Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055).

Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen.

Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain.

Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain.

Integrin ITGAM/ITGB2 is also a receptor for factor X.

Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1.

Contributes to natural killer cell cytotoxicity (PubMed:15356110).

Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980).

Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400).

Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).

In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407).

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