Human Integrin Β2, ITG B2 ELI

Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4.

Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed: 29100055).

Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen.

Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain.

Integrin ITGAM/ITGB2 recognizes P1 and P2 Peptides of fibrinogen gamma chain.

Integrin ITGAM/ITGB2 is also a receptor for factor X.

Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1.

Contributes to natural killer cell cytotoxicity (PubMed: 15356110).

Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed: 11812992, PubMed: 28807980).

Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed: 18587400).

Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed: 23775590).

In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed: 21193407).