Human Intercellular Adhesion Molecule 2, ICAM-2 ELI

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion.

It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.