Human Interferon Alpha-inducible Protein 6, IFI6 ELI

Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (PubMed: 15685448, PubMed: 17823654, PubMed: 26244642).

However, it has also been shown to have a pro-apoptotic activity (PubMed: 27673746).

Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, which activation is required for entry of the virus into cells (PubMed: 25757571).