Human Interferon-induced Gtp-binding Protein Mx2, MX2 ELI

Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1).

Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA.

Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd).

May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.