Human Interferon-induced Protein with Tetratricopeptide Repeats 2, IFIT2 ELI

IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap.

The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection.

Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism).

Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity.

Can promote apoptosis.