Human Interleukin 1 Receptor Accessory Protein, IL1RAP ELI

Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity).

Coreceptor with IL1R1 in the IL-1 signaling system.

Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways.

Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits.

Recruits TOLLIP to the signaling complex.

Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex.

The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor.

Coreceptor for IL1RL1 in the IL-33 signaling system.

Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).

May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable).

[Isoform 2]: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed: 12530978).

Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity).

[Isoform 4]: Unable to mediate canonical IL-1 signaling (PubMed: 19481478).

Required for Src phosphorylation by IL1B.

May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity).