Human Interleukin-1 Receptor-Like 1, IL1RL1 Primacu™ ELI
3,970.00 ₪
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia.
It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease.
The ligand for IL1RL1 has been described and named IL-33.
Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies.
As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage proinflammatory function.
IL33 is a specific ligand of ST2L and induces the production of Th2 cytokines.
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