Human Interleukin-1 Receptor-like 2, IL1RL2 ELI

Receptor for interleukin-36 (IL36A, IL36B and IL36G).

After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity).

The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system.

Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.