Human Interleukin-15 Receptor Subunit Alpha, IL15RA ELI

High-affinity receptor for interleukin-15 (PubMed: 8530383).

Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity).

In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (PubMed: 15123770).

In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (PubMed: 15123770).

Expression of different isoforms may alter or interfere with signal transduction (PubMed: 10480910).

[Isoform 5]: Does not bind IL15.

[Isoform 6]: Does not bind IL15.

[Isoform 7]: Does not bind IL15.

[Isoform 8]: Does not bind IL15.