Human Interleukin-17 Receptor D, IL17RD ELI

Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation (PubMed: 12958313, PubMed: 12807873).

Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK (PubMed: 15239952).

Mediates JNK activation and may be involved in apoptosis (By similarity).

May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity).

Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity).

Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).