Human Interleukin-18-Binding Protein, IL18BP Primacu™ ELI
3,970.00 ₪
Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein.
IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family.
This receptor specifically binds interleukin 18 (IL18) and is essential for IL18 mediated signal transduction.
IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells.
This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.
The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy.
IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS.
A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.
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