Human Interleukin-18 Receptor 1, IL18R1 ELI

Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (PubMed: 8626725, PubMed: 14528293, PubMed: 25261253, PubMed: 25500532).

Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed: 10653850).

Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).