Human Interleukin 1Β, IL-1B ELI

Potent proinflammatory cytokine.

Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.

Promotes Th17 differentiation of T-cells.

Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed: 10653850).

Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed: 12794819).