Human Interleukin-20, IL20 Primacu™ ELI
3,970.00 ₪
IL20/Interleukin-20 belongs to the IL-10 family.
It is a cytokine structurally related to interleukin 10.
IL20/Interleukin-20 can be detected in skin, trachea, and other tissues.
It is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells.
It has been shown that interleukin-20 transduces its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes.
It may be involved in epidermal function and psoriasis.
It also regulates the proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin.
Also, IL20/Interleukin-20 also causes cell expansion of multipotential hematopoietic progenitor cells.
A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.
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