Human Interleukin-36 Receptor Antagonist Protein, IL1F5 ELI

Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling.

Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor.

Proposed to play a role in skin inflammation.

May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.

May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.