Human Interleukin-6 receptor subunit alpha,IL6RA ELI

Part of the receptor for interleukin 6.

Binds to IL6 with low affinity, but does not transduce a signal (PubMed:28265003).

Signal activation necessitate an association with IL6ST.

Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis (Probable).

The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system.

Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'.

Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable).

{ECO:0000269|PubMed:28265003, ECO:0000305|PubMed:30995492}.; [Isoform 1]: Signaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory (Probable).

Drives naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells (By similarity).

{ECO:0000250|UniProtKB:P22272, ECO:0000305|PubMed:30995492}.; [Isoform 2]: Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed:21990364).

The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'.

sIL6R is causative for the proinflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (PubMed:21990364).

In complex with IL6, is required for induction of VEGF production (PubMed:12794819).

Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity).

'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity).

{ECO:0000250|UniProtKB:P22272, ECO:0000269|PubMed:12794819, ECO:0000269|PubMed:21990364}.; [Soluble interleukin-6 receptor subunit alpha]: Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed:21990364).

The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'.

sIL6R is causative for the proinflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (PubMed:21990364).

In complex with IL6, is required for induction of VEGF production (PubMed:12794819).

Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity).

'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity).

{ECO:0000250|UniProtKB:P22272, ECO:0000269|PubMed:12794819, ECO:0000269|PubMed:21990364}.