Human Junctional Adhesion Molecule A, F11R ELI

Seems to play a role in epithelial tight junction formation.

Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed: 11489913).

The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity).

Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity).

Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed: 11812992).

Involved in platelet activation (PubMed: 10753840).

(Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.

(Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.