Human L-asparaginase,ASRGL1 ELI

Has both L-asparaginase and beta-aspartyl peptidase activity.

May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions.

Is highly active with L-Asp beta-methyl ester.

Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys.

Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn.

Likewise, has no activity toward glutamine.

{ECO:0000269|PubMed:19839645, ECO:0000269|PubMed:27106100}.