Human Leucine-rich Repeat Transmembrane Protein Flrt2, FLRT2 ELI

Functions in cell-cell adhesion, cell migration and axon guidance.

Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells.

May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D.

Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members.

Plays a role in fibroblast growth factor-mediated signaling cascades.

Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.