Human Leukocyte-associated immunoglobulin-like receptor 1,LAIR1 ELI

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells.

Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11.

It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.

May also play its inhibitory role independently of SH2-containing phosphatases.

Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta.

Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion.

Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells.

Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

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