Human Leukocyte Immunoglobulin-like Receptor Subfamily B Member 4, LILRB4 ELI

Receptor for class I MHC antigens.

Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.

Involved in the down-regulation of the immune response and the development of tolerance, e.g.

towards transplants.

Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation.

Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.