Human Lim and Calponin Homology Domains-containing Protein 1, LIMCH1 ELI

Actin stress fibers-associated protein that activates non-muscle myosin IIa.

Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9.

Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions.

It therefore negatively regulates cell spreading and cell migration.