Human Low Affinity Immunoglobulin Gamma Fc Region Receptor 2B, FCGR2B ELI

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma.

Low affinity receptor.

Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.

Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor.

Isoform IIB1 fails to mediate endocytosis or phagocytosis.

Isoform IIB2 does not trigger phagocytosis.