Human Lysosomal-associated transmembrane protein 4B,LAPTM4B ELI

Required for optimal lysosomal function (PubMed:21224396).

Blocks EGF-stimulated EGFR intraluminal sorting and degradation.

Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945).

Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567).

Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825).

Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).

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