Human Macrophage-Derived Chemokine,MDC ELI

May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology.

Chemotactic for monocytes, dendritic cells and natural killer cells.

Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes.

Binds to CCR4.

Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.