Human Macrophage Inflammatory Protein-3Β, MIP-3B ELI

May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing.

May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs.

Binds to chemokine receptor CCR7.

Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes.

Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.