Human Mannan-binding lectin,MBP ELI
3,140.00 ₪
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS.
They have a role in both its formation and stabilization.
The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis.
The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells.
Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function.
Induces T-cell proliferation.
{ECO:0000269|PubMed:8544862}.
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