Human Mannose-6-Phosphate Receptor,M6PR ELI

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes.

Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.