Human Matrin-3, MATR3 ELI

May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network.

In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs.

Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed: 28712728).

May bind to specific miRNA hairpins (PubMed: 28431233).