Human Matrix Metalloproteinase 1, MMP-1 ELI

Cleaves collagens of types I, II, and III at one site in the helical domain.

Also cleaves collagens of types VII and X (PubMed: 2557822, PubMed: 2153297, PubMed: 1645757).

In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed: 16807369).