Human Matrix Metalloproteinase-17, MMP17 ELI

Endopeptidase that degrades various components of the extracellular matrix, such as fibrin.

May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha.

May also be involved in tumoral process.

Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site.

Not obvious if able to proteolytically activate progelatinase A.

Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.