Human Melanoma-associated Antigen D1, MAGED1 ELI

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells.

Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis.

May act as a regulator of the function of DLX family members.

May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.

Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Plays a role in the circadian rhythm regulation.

May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.