Human Membrane-associated progesterone receptor component 2,PGRMC2 ELI

Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity).

May serve as a universal non-classical progesterone receptor in the uterus (Probable).

Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity).

Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073).

In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity).

{ECO:0000250|UniProtKB:Q80UU9, ECO:0000269|PubMed:28111073, ECO:0000305|PubMed:28396637}.