Human Mitofusin-1,MFN1 ELI
3,140.00 ₪
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303).
Membrane clustering requires GTPase activity (PubMed:27920125).
It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303).
Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376).
Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376).
Has low GTPase activity (PubMed:27920125, PubMed:28114303).
{ECO:0000269|PubMed:12475957, ECO:0000269|PubMed:12759376, ECO:0000269|PubMed:27920125, ECO:0000269|PubMed:28114303}.
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