Human Monocyte Chemotactic Protein 4, MCP-4 ELI

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils.

Signals through CCR2B and CCR3 receptors.

Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation.

May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.

May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.